| Nur Heimspiele | Nur Auswärtsspiele |
| Datum | Spielpaarung | | | 1 | Sa, 05.09.2020 | SC Freiburg II - FSV Frankfurt | 14.00 |
| 2 | Sa, 12.09.2020 | FSV Frankfurt - FC Bayern Alzenau | 14.00 |
| 3 | Mi, 16.09.2020 | SSV Ulm 1846 - FSV Frankfurt | 19.00 |
| 4 | Sa, 19.09.2020 | FSV Frankfurt - FC Gießen | 14.00 |
| 5 | Sa, 26.09.2020 | VfB Stuttgart II - FSV Frankfurt | 14.00 |
| 6 | Di, 29.09.2020 | FSV Frankfurt - TSV Schott Mainz | 19.00 |
| 7 | Sa, 03.10.2020 | TSV Eintracht Stadtallendorf - FSV Frankfurt | 14.00 |
| 8 | Sa, 10.10.2020 | FSV Frankfurt - KSV Hessen Kassel | 14.00 |
| 9 | Sa, 17.10.2020 | FC 08 Homburg - FSV Frankfurt | 14.00 |
| 10 | Di, 20.10.2020 | FSV Frankfurt - SV 07 Elversberg | 19.00 |
| 11 | Sa, 24.10.2020 | TuS Rot-Weiß Koblenz - FSV Frankfurt | 14.00 |
| 12 | Sa, 31.10.2020 | FSV Frankfurt - FK Pirmasens | 14.00 |
| 13 | Di, 03.11.2020 | FSV Frankfurt - FC-Astoria Walldorf | 19.00 |
| 14 | Sa, 07.11.2020 | VfR Aalen - FSV Frankfurt | 14.00 |
| 15 | Sa, 14.11.2020 | FSV Frankfurt - 1. FSV Mainz 05 II | 14.00 |
| 16 | Sa, 21.11.2020 | Bahlinger SC - FSV Frankfurt | 14.00 |
| 17 | Sa, 28.11.2020 | FSV Frankfurt - SG Sonnenhof Großaspach | 14.00 |
| 18 | Sa, 05.12.2020 | Kickers Offenbach - FSV Frankfurt | 14.00 |
| 19 | Sa, 12.12.2020 | FSV Frankfurt - TSG 1899 Hoffenheim II | 14.00 |
| 20 | Sa, 19.12.2020 | TSG Balingen - FSV Frankfurt | 14.00 |
| 21 | Sa, 30.01.2021 | FSV Frankfurt - TSV Steinbach Haiger | 14.00 |
| 22 | Sa, 06.02.2021 | FSV Frankfurt - SC Freiburg II | 14.00 |
| 23 | Sa, 13.02.2021 | FC Bayern Alzenau - FSV Frankfurt | 14.00 |
| 24 | Sa, 20.02.2021 | FSV Frankfurt - SSV Ulm 1846 | 14.00 |
| 25 | Sa, 27.02.2021 | FC Gießen - FSV Frankfurt | 14.00 |
| 26 | Sa, 06.03.2021 | FSV Frankfurt - VfB Stuttgart II | 14.00 |
| 27 | Sa, 13.03.2021 | TSV Schott Mainz - FSV Frankfurt | 14.00 |
| 28 | Sa, 20.03.2021 | FSV Frankfurt - TSV Eintracht Stadtallendorf | 14.00 |
| 29 | Sa, 27.03.2021 | KSV Hessen Kassel - FSV Frankfurt | 14.00 |
| 30 | Sa, 03.04.2021 | FSV Frankfurt - FC 08 Homburg | 14.00 |
| 31 | Sa, 10.04.2021 | SV 07 Elversberg - FSV Frankfurt | 14.00 |
| 32 | Sa, 17.04.2021 | FSV Frankfurt - TuS Rot-Weiß Koblenz | 14.00 |
| 33 | Di, 20.04.2021 | FK Pirmasens - FSV Frankfurt | 19.00 |
| 34 | Sa, 24.04.2021 | FC-Astoria Walldorf - FSV Frankfurt | 14.00 |
| 35 | Sa, 01.05.2021 | FSV Frankfurt - VfR Aalen | 14.00 |
| 36 | Di, 04.05.2021 | 1. FSV Mainz 05 II - FSV Frankfurt | 19.00 |
| 37 | Sa, 08.05.2021 | FSV Frankfurt - Bahlinger SC | 14.00 |
| 38 | Sa, 15.05.2021 | SG Sonnenhof Großaspach - FSV Frankfurt | 14.00 |
| 39 | Sa, 22.05.2021 | FSV Frankfurt - Kickers Offenbach | 14.00 |
| 40 | Sa, 29.05.2021 | TSG 1899 Hoffenheim II - FSV Frankfurt | 14.00 |
| 41 | Sa, 05.06.2021 | FSV Frankfurt - TSG Balingen | 14.00 |
| 42 | Sa, 12.06.2021 | TSV Steinbach Haiger - FSV Frankfurt | 14.00 |
